TrxR2-IN-1

SKU: orb3210650

Description

TrxR2-IN-1 is an inhibitor of thioredoxin reductase 2 (TrxR2) with an IC50 value of 0.83 μM. It accumulates in mitochondria, disrupting their function and membrane potential, elevating reactive oxygen species (ROS) levels, and activating ASK1-mediated caspase-dependent apoptosis. TrxR2-IN-1 induces G2/M phase cell cycle arrest and inhibits cancer cell migration, making it applicable for hepatocellular carcinoma research.

Key Properties

• CAS Number: 3085154-16-8
• MW: 819.89
• Formula: C₅₀H₆₀BrO₃P
• SMILES: C[C@]12[C@]3([C@]4(C[C@](OCCCCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)(C(=C)C4)CC3)CC[C@@]1([C@@](C(OCC8=CC=CC=C8)=O)(C)CCC2)[H])[H].[Br-]
• Target: ROS,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,Apoptosis,Caspase