TrxR-IN-5

SKU: orb1688389

Description

TrxR-IN-5 (4f) is a potent thioredoxin reductase inhibitor (IC₅₀ = 0.16 µM). It elevates intracellular ROS, reverses TGFβ1-induced EMT, and demonstrates anti-proliferative and anti-metastatic activity in human breast cancer cell models, supporting its investigation in oncology research.

Research Area

Immunology & Inflammation

Key Properties

• MW: 382.46
• Formula: C₂₆H₂₂O₃
• SMILES: O=C1C=CCC/C1=C/C2=CC=C(OC3=CC=C(/C=C4CCC=CC\4=O)C=C3)C=C2
• Target: ROS,Others
• Solubility: DMSO:40 mg/mL (104.59 mM)

Bioactivity

• Target IC50:
  TrxR:0.16 ± 0.02 μM
• In Vivo:
  In the MDA-MB-231 parazacco spilurus subsp. spilurus xenograft model of BALB/c nude mice, TrxR-IN-5 (compound 4f) (0-25 mg/kg, intraperitoneal injection, once) significantly inhibited the growth of breast cancer solid tumors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,Others