TRV-120027 TFA

SKU: orb1296359

Description

TRV-120027 TFA is a β-arrestin-biased AT1R agonist that selectively inhibits angiotensin II-mediated G-protein signaling while promoting β-arrestin-1 recruitment. This action inhibits vasoconstriction, enhances cardiomyocyte contractility, and triggers catecholamine secretion via a macromolecular AT1R–β-arrestin-1–TRPC3–PLCγ complex. It is a valuable research tool for studying biased GPCR signaling in cardiovascular physiology and disease models.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• Target: TRP/TRPV Channel,Arrestin,RAAS
• MW: 1040.1
• Purity: 97.45% (May vary between batches)
• Formula: C₄₅H₆₈F₃N₁₃O₁₂
• SMILES: O=C(O)C(F)(F)F.C[C@H](C(O)=O)NC([C@H]1N(C([C@H](CC2=CNC=N2)NC([C@]([C@H](C)CC)([H])NC([C@@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)=O)=O)=O)CCC1)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1234510-46-3, 1234510-46-3 free base, AT1 receptor, the angiotensin II receptor type 1, TRP Channel, TRPChannel, TRPV Channel, TRPVChannel, TRV 120027 TFA, TRV120027 TFA, TRV-120027 TFA, TRV-120027 TFA (1234510-46-3 free base)

Compound Identifiers

PubChem CID

163285886