TRPA1-IN-2

SKU: orb1819093

Description

TRPA1-IN-2 is a potent, orally bioavailable inhibitor of the TRPA1 ion channel, demonstrating an IC50 of 40 nM. Its anti-inflammatory properties support its use in research for studying pain and inflammation mechanisms in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2415206-22-1
• MW: 442.48
• Purity: 98.05% (May vary between batches)
• Formula: C₂₄H₂₅F₃N₄O
• SMILES: C(=O)(C1(NC2=CC=C(C#N)C=C2)CCCC1)N3CCN(CC3)C4=CC=C(C(F)(F)F)C=C4
• Target: TRP/TRPV Channel
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (5.65 mM);DMSO:50 mg/mL (113 mM)

Bioactivity

• Target IC50:
  TRPA1:0.04 μM
• In Vivo:
  TRPA1-IN-2 (90 mg/kg, i.p. in mice; 30 mg/kg, i.p. in rats; 100 mg/kg, orally) reduced the total number of white blood cells and eosinophils in BALF, demonstrating anti-inflammatory activity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TRPVChannel, TRPV Channel, TRPChannel, TRP Channel, TRPA1IN2, TRPA1-IN-2, TRPA1

Compound Identifiers

PubChem CID

155367197