Troxerutin

SKU: orb1310306

Description

Troxerutin, a trihydroxyethylated rutin derivative sourced from Sophora japonica, is a bioactive flavonoid for research use. It is employed in vitro and in vivo to study its potential effects on vascular permeability, inflammation, and oxidative stress.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 7085-55-4
• MW: 742.68
• Purity: 95.00% (May vary between batches)
• Formula: C₃₃H₄₂O₁₉
• SMILES: O(C1=C(OC=2C(C1=O)=C(O)C=C(OCCO)C2)C3=CC(OCCO)=C(OCCO)C=C3)[C@@H]4O[C@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@H]4O
• Target: NOD-like Receptor (NLR)
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:262.5 mg/mL (353.45 mM);H2O:92 mg/mL (123.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.69 mM)

Bioactivity

• In Vivo:
  Troxerutin contributes to the reduction of red blood cell aggregation and enhances microvascular perfusion, beneficially affecting complications of chronic venous insufficiency. It mitigates oxidative stress and cognitive impairment induced by D-galactose by lowering levels of protein carbonyl groups, reactive oxygen species, and advanced glycation end-products while also boosting the activation of PI3K/Akt. Additionally, troxerutin reduces the levels of α-aminoadipic acid, homocysteine, triglycerides, cholesterol, and low-density lipoprotein apolipoprotein B in patients with acute myocardial infarction.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, NODlike Receptor (NLR), NOD-like Receptor, NOD-like Receptor (NLR), NODlikeReceptor, NODlikeReceptor(NLR), NLR, Troxerutin, Trihydroxyethylrutin

Compound Identifiers

PubChem CID

5486699