TrkA-IN-3

SKU: orb1744280

Description

TrkA-IN-3 is a highly potent and subselective allosteric inhibitor of TrkA (IC50 = 22.4 nM) with >8000-fold selectivity over TrkB/C. Its profile makes it a valuable chemical probe for investigating TrkA-specific signaling in pain pathways, suitable for both in vitro biochemical assays and in vivo pain research models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3026111-73-6
• MW: 466.41
• Purity: 98.37% (May vary between batches)
• Formula: C₂₄H₁₇F₃N₄O₃
• SMILES: O=C(O)C1=CN=C(C=2C=CC=CC2)C(=C1)NC(=O)C=3C=CC(=C(C3)C4=NN(C=C4)C)C(F)(F)F
• Target: Trk receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166176996