TRK-IN-34

SKU: orb3210821

Description

TRK-IN-34 is an orally active inhibitor targeting mutant kinases TRKA and TRKC, exhibiting IC50 values of 0.75 nM and 0.96 nM for TRKAG595R and TRKAG667C, respectively. It effectively inhibits the kinase activities of TRKAG595R and TRKAG667C at a functional level. TRK-IN-34 suppresses cell proliferation transfected with TRKA and demonstrates tumor growth inhibition and partial tumor regression in xenograft models. This compound is useful for studying cancers with TRK inhibitor-resistance driven by the TRKAG667C mutation.

Key Properties

• CAS Number: 2489327-91-3
• MW: 420.36
• Formula: C₁₉H₁₆F₄N₆O
• SMILES: N([C@H](C)C1=C(OCC(F)(F)F)C=CC(F)=C1)C2=NC3=C(C=NN3C=C2)C=4C=NNC4
• Target: Trk receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Trk receptor