TRK-IN-23

SKU: orb1944398

Description

TRK-IN-23 (compound 24b) is a potent and orally bioavailable pan-TRK inhibitor, demonstrating low nanomolar IC50 values against wild-type TRKA and key solvent-front mutants. It effectively induces apoptosis in Ba/F3 cells harboring TRKA mutations, supporting its utility in preclinical cancer research for studying TRK-driven oncogenesis and resistance mechanisms.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2924344-29-4
• MW: 364.37
• Purity: 97.01% (May vary between batches)
• Formula: C₂₀H₁₇FN₄O₂
• SMILES: C(=C\1/C=2C(NC1=O)=CC=C(NCC3=C(OC)C=CC(F)=C3)C2)\C4=CN=CN4
• Target: Trk receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168475926