TRK-IN-12

SKU: orb1687513

Description

TRK-IN-12 (Compound 9e) is a potent macrocyclic TRK inhibitor, effective against the G595R resistance mutation. It shows strong antiproliferative activity in relevant Ba/F3 cell models, outperforming LOXO-101 in the G595R-mutant line. This inhibitor is a valuable tool for studying TRK-driven cancers and resistance mechanisms in both in vitro and in vivo research contexts.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2823342-34-1
• MW: 439.89
• Formula: C₁₈H₁₉ClFN₅O₃S
• SMILES: S(CCl)(=O)(=O)N1CC2=C3N(N=C2)C=CC(=N3)N(C)CC=4C(OCC1)=CC=C(F)C4
• Target: Others,Trk receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163196402