Triptriolide

SKU: orb3024460

Description

Triptriolide inhibits puromycin aminonucleoside (PAN)-induced apoptosis in mouse podocytes by modulating Bcl-2 family proteins and suppressing Caspase-3. It also promotes cell survival and protects podocyte function by activating the TAK1-NF-κB signaling pathway and upregulating the podocyte protein podocin.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 137131-18-1
• MW: 378.416
• Formula: C₂₀H₂₆O₇
• SMILES: C[C@@]12[C@@]34[C@@]5([C@@](O5)(C[C@]1(C6=C(CC2)C(=O)OC6)[H])[H])[C@H](O)[C@@]([C@@H](C)C)(O)[C@H](O)[C@@]3(O4)[H]
• Target: Apoptosis,NF-κB,MAPK,MAP3K

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,NF-κB,MAPK,MAP3K