Trimethoprim

SKU: orb1309588

Description

Trimethoprim (NSC-106568) is a small molecule antibacterial agent that primarily functions as a dihydrofolate reductase (DHFR) inhibitor. It is widely used in research to study antibiotic mechanisms and bacterial resistance, both in vitro and in animal infection models. Additionally, it exhibits inhibitory activity against cytochrome P450 2C8 and organic cation transporter 2.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 738-70-5
• MW: 290.32
• Purity: 99.80% (May vary between batches)
• Formula: C₁₄H₁₈N₄O₃
• SMILES: COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC
• Target: Antifolate,Antibiotic,DHFR,DNA/RNA Synthesis,Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.78 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:122 mg/mL (420.23 mM)

Bioactivity

• In Vivo:
  Trimethoprim acts by interfering with the bacterial dihydrofolate reductase, inhibiting the synthesis of tetrahydrofolic acid. This inhibition causes a deficiency in nucleotides essential for bacterial DNA replication, which in some instances leads to cell death due to thymineless death.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

aggregation, Antimicrobial, Antifolate, Antibiotic, Bacterial, BW 56-72, dihydrofolate, DHFR, DNA Synthesis, DNASynthesis, NIH 204, NIH204, NIH-204, NSC106568, NSC-106568, metabolism, Inhibitor, NSC 106568, inhibit, Influenza Virus, Hsps, folate, protein, RNASynthesis, RNA Synthesis, reductase, Shigellosis, Pneumocystis pneumonia, Thymidylate synthase, urinary tract infections, Trimethoprim, tetrahydrofolate

Compound Identifiers

PubChem CID

5578