Triflusal

SKU: orb1310367

Description

Triflusal (UR1501) is a small molecule structurally analogous to aspirin, specifically 2-acetoxy-4-trifluoromethylbenzoic acid. It has been utilized in cardiovascular and neurovascular research, with studies investigating its antiplatelet and anti-inflammatory effects in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Neuroscience

Key Properties

• CAS Number: 322-79-2
• MW: 248.16
• Purity: 99.82% (May vary between batches)
• Formula: C₁₀H₇F₃O₄
• SMILES: CC(=O)Oc1cc(ccc1C(O)=O)C(F)(F)F
• Target: PPAR,PDE,COX
• Solubility: DMSO:40 mg/mL (161.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (10.07 mM);Ethanol:47 mg/mL (189.39 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  COX-2:160 μM (IC50, in human blood)|COX-2:280 μM (IC50)
• In Vivo:
  Triflusal (10 mg/kg i.v.) reduces platelet deposition on subendothelium-induced primary thrombus by about 68% in rabbits. Triflusal (10 mg/kg i.v.) reduces platelet deposition on a fresh thrombus formed over tunica media by about 48% in rabbits. Triflusal (40 mg/kg p.o.) reduces platelet deposition on a primary thrombus triggered by subendothelium and tunica media by 53% in rabbits. Triflusal (40 mg/kg p.o.) significantly reduces Cox-2 mRNA levels and protein levels without influence Cox-1 mRNA levels on the vascular wall in rabbits. Triflusal (600 mg/day for 5 days) results in an increase in NO production by neutrophils and an increase in endothelial nitric oxide synthase (eNOS) protein expression in neutrophils in healthy volunteers. Triflusal (300 mg, twice-daily orally) shows a more important increase in total walking distance and in pain-free walking distance over the basal values than those treated with placebo, together with an improvement of the symptomatology correlated with claudication in patients with chronic peripheral arteriopathy. Triflusal (300 mg, twice-daily orally) shows an increase in the peak-flow recorded through strain-gauge plethysmography in patients with chronic peripheral arteriopathy. Triflusal (30 mg/kg) strongly decreases iNOS immunolabeling at both survival times analyzed, attenuating iNOS immunoreactivity in astroglial cells and infiltrated neutrophils in rats. Triflusal (30 mg/kg) decreases neuronal and microglial COX-2 expression at 10 and 24 hours after lesion and microglial and astroglial expression of IL-1beta and TNF-alpha at 24 hours after lesion in rats.
• In Vitro:
  The main Triflusal metabolite, HTB, preserves 6-keto-PGF1α synthesis in porcine aortic endothelial cells (PAEC) cells without a significant decline for up to 24 h even at the higher concentration. Triflusal at 10 mM, 100 mM and 1 M decreases LDH efflux in rat brain slices after anoxia/reoxygenation by 24%, 35% and 49% respectively. Triflusal also reduces inducible NO synthase activity by 18%, 21% and 30%.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclooxygenase, COX, Inhibitor, inhibit, PDE, UR 1501, UR1501, UR-1501, TXA2R, Triflusal

Compound Identifiers

PubChem CID

9458