Triclosan

SKU: orb1225265

Description

Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments.

Key Properties

• CAS Number: 3380-34-5
• MW: 289.54
• Purity: >98% (HPLC)
• Formula: C₁₂H₇Cl₃O₂
• SMILES: OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
• Target: NADPH
• Solubility: DMSO: > 10 mM

Bioactivity

• In Vivo:
  Animal model: Wild type BALB/cJ mice. Dosage: 5, 50, 500 mg/kg. Administration: Oral gavage, five days a week for a total of four weeks. Result: Caused an increase in the production of anti-dermatophagoides farinae (Der f) IgE, IL‐4, and IL‐13, and this resulted in the aggravation of airway hyperresponsiveness in aeroallergen‐exposed wild type mice.
• In Vitro:
  Cell Viability Assay Cell line: Neural stem wells. Concentration: 1, 10, 20, 30, 50 and 100 μM. Incubation time: 24 h. Result: Initiated the decreases in cell viability in dose and time dependent manners with 50 and 100 μM. Differentially induced the increased expressions of both phosphorylated p38 and JNK proteins.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Triclosan

Quick Database Links

Gene Symbol

NADPH