Triclabendazole

SKU: orb1310247

Description

Triclabendazole (CGA89317) is a benzimidazole anthelmintic compound extensively utilized in parasitology research. It is primarily employed in in vitro and in vivo studies for investigating trematode infections, notably fascioliasis, due to its potent activity against immature and mature liver flukes.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 68786-66-3
• MW: 359.66
• Purity: 98.35% (May vary between batches)
• Formula: C₁₄H₉Cl₃N₂OS
• SMILES: CSC1=NC2=C(N1)C=C(Cl)C(OC1=C(Cl)C(Cl)=CC=C1)=C2
• Target: Microtubule Associated|||Parasite
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:60 mg/mL (166.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.56 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  Triclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3% and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm. Triclabendazole sulphoxide (50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica, whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of the tegument covering the spines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGA 89317, CGA89317, CGA-89317, Inhibitor, inhibit, Parasite, Microtubule/Tubulin, MicrotubuleAssociated, Microtubule Associated, Triclabendazole, Tubulin

Compound Identifiers

PubChem CID

50248