Tribendimidine

SKU: orb2900780

Description

Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist.

Key Properties

• CAS Number: 115103-15-6
• MW: 452.59
• Purity: >98% (HPLC)
• Formula: C₂₈H₃₂N₆
• SMILES: CN(C)C(\C)=N\c1ccc(cc1)\N=C\c1ccc(\C=N\c2ccc(cc2)\N=C(/C)N(C)C)cc1
• Target: AChR
• Solubility: In Vitro: DMSO : 50 mg/mL (110.48 mM; Ultrasonic; (HCL ，pH≈3); )

Bioactivity

• In Vivo:
  Tribendimidine (75 and 150 mg/kg; p.o. ; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters. Animal model: C. sinensis infected Female Wistar rats. Dosage: 75 mg/kg and 150 mg/kg. Administration: Oral administration, once. Result: A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.
• In Vitro:
  Tribendimidine (100 μg/mL; 24 h) shows intoxication of C. elegans. Tribendimidine (0-100 μg/mL; 6 days) shows toxicity with an LC50 value (concentration at which half the animals are dead) of 54.4 μg/mL. Tribendimidine (0-200 μg/mL; 64 h)-induced sterility is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants are resistant to Tribendimidine.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AChR