Triacetylresveratrol

SKU: orb1301602

Description

Triacetylresveratrol is a bioactive small molecule with demonstrated anti-cancer properties, particularly in pancreatic cancer research. It functions by inhibiting STAT3 and NFκB signaling, modulating Bcl-2 family proteins to promote apoptosis. This compound is used in vitro and in vivo to study apoptotic pathways and potential therapeutic strategies.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 42206-94-0
• MW: 354.35
• Purity: 98.00%
• Formula: C₂₀H₁₈O₆
• SMILES: CC(=O)Oc1ccc(\C=C\c2cc(OC(C)=O)cc(OC(C)=O)c2)cc1
• Target: Bcl-2 Family,NF-κB,STAT
• Solubility: DMSO:50 mg/mL (141.1 mM)

Bioactivity

• In Vivo:
  Acetyl-trans-resveratrol significantly inhibited intracranial tumor growth and prolonged survival in these mouse models.
• In Vitro:
  Acetyl-trans-resveratrol inhibited cell viability, and induced apoptosis of pancreatic cancer cells in a concentration and incubation time-dependent manner.
• Cell Research:
  Apoptosis was determined by using apoptosis detection kit according to the manufacturers instructions. Briefly, cells were treated with the indicated dosage of Acetyl-trans-resveratrol for 48 h. The untreated and treated cells were washed with PBS buffer and gently suspended in Annexin V binding buffer and incubated with Annexin V-FITC (20 μg/mL) and PI (20 μg/mL) for 15 minutes in the dark. Flow cytometry analysis was performed using Cellquest software.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Mcl-1, PANC-1, NF-κB, Nuclear factor-κB, Nuclear factor-kappaB, NFκB, NFkB, NF-kB, inhibit, BxPC-3, Anticancer, Acetyl-trans-resveratrol, Resveratrol, STAT3, STAT, Triacetylresveratrol

Compound Identifiers

PubChem CID

5962587