TRI-611

SKU: orb3177572

Description

TRI-611 is a highly selective ALK molecular chaperone degrader that can cross the blood-brain barrier. By binding to the CRBN E3 ligase, it induces the ubiquitination and proteasomal degradation of ALK fusion proteins. TRI-611 efficiently degrades various EML4-ALK fusion proteins, including TKI-resistant mutants, and demonstrates significant antitumor activity in ALK-positive non-small cell lung cancer (NSCLC) models. TRI-611 induces tumor regression in subcutaneous and intracranial xenograft models and is equally effective in models resistant to ALK tyrosine kinase inhibitors (TKIs), making it a valuable tool for research into ALK-driven tumors and resistance mechanisms.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3117940-39-0
• MW: 404.38
• Purity: 99.37% (May vary between batches)
• Formula: C₂₁H₁₆N₄O₅
• SMILES: O=C1OC2=CC=C(C=C2N1C3C(=O)NC(=O)CC3)CC4=NC(=NO4)C=5C=CC=CC5
• Target: Molecular Glues,ALK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Molecular Glues,ALK