TRF1-TIN2 interaction-IN-1

SKU: orb3027474

Description

TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.

Research Area

Molecular Biology

Key Properties

• MW: 374.41
• Formula: C₁₉H₁₈O₆S
• SMILES: OS(C1=CC=C(OCC2=CC(OC)=CC(OC)=C2)C3=C1C=CC=C3)(=O)=O
• Target: Telomerase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Telomerase