TRAP-14

SKU: orb3053977

Description

Sfllrnpndkyepf is a synthetic thrombin receptor agonist peptide.

Key Properties

• CAS Number: 137339-65-2
• MW: 1739.96
• Purity: >98% (HPLC)
• Formula: C₈₁H₁₁₈N₂₀O₂₃
• Solubility: H2O : ≥ 100 mg/mL (57.47 mM)

Bioactivity

• In Vitro:
  Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence TRAP-14. This peptide (TRAP-14) may signal a variety of thrombin's responses. TRAP-14, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. TRAP-14, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. TRAP-14 is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only