Tranylcypromine (2-PCPA) hydrochloride

SKU: orb1310020

Description

Tranylcypromine hydrochloride is a potent and irreversible monoamine oxidase inhibitor (MAOI). It is widely used in research to study depression models, particularly atypical and treatment-resistant forms, in both in vitro enzyme assays and in vivo behavioral experiments.

Research Area

Epigenetics & Chromatin, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 1986-47-6
• MW: 169.66
• Purity: 99.86% (May vary between batches)
• Formula: C₉H₁₁N·HCl
• SMILES: N[C@H]1[C@H](C2=CC=CC=C2)C1.Cl
• Target: Histone Demethylase,MAO,Monoamine Oxidase
• Solubility: H2O:17 mg/mL (100.2 mM);DMSO:250 mg/mL (1473.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.79 mM)

Bioactivity

• Target IC50:
  MAO-B:7 μM|MAO-A:11.5 μM|LSD1:22.3 μM
• In Vivo:
  In bovine aortic endothelial cells, Tranylcypromine (500 μg/mL) markedly inhibits bradykinin-induced release of arachidonic acid. Additionally, Tranylcypromine suppresses the activity of CYP2A6 (IC50: 0.42 μM) and CYP2E1 (IC50: 3 μM) in human liver microsomes (HLMs), inducing type II and cyclopropylbenzene type I difference spectra in HLMs. Nicotine metabolism mediated by CYP2A6 in HLMs is completely inhibited by R-(+)-Tranylcypromine (Ki: 0.05 μM), (±)-Tranylcypromine (Ki: 0.08 μM), and S-(-)-Tranylcypromine (Ki: 2.0 μM).
• In Vitro:
  Compared with the control group, Tranylcypromine at dosages of 5 mg/kg and 10 mg/kg significantly and gradually increased muscle activity in male rats; however, a 2 mg/kg dosage of Tranylcypromine had no effect. Additionally, Tranylcypromine administered at 10 mg/kg markedly increased the number of copulatory behaviors in male rats.

Storage & Handling

• Storage: store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histone Demethylase, HistoneDemethylase, MAO, LSD1, SKF-385 HCl, Tranylcypromine (2 PCPA) hydrochloride, Tranylcypromine (2-PCPA) HCl, Tranylcypromine (2PCPA) hydrochloride, Tranylcypromine (2-PCPA) Hydrochloride

Compound Identifiers

PubChem CID

2723716