trans-isrib A17

SKU: orb1685572

Description

trans-ISRIB A17 (ISR-IN-1) is a highly potent small molecule inhibitor of the integrated stress response (ISR), exhibiting an EC50 of 0.6 nM. It is widely used in both in vitro and in vivo research to study ISR pathway biology, cellular stress mechanisms, and potential therapeutic interventions for related diseases.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1628478-15-8
• MW: 487.32
• Purity: 98.36% (May vary between batches)
• Formula: C₂₂H₂₂Cl₂F₂N₂O₄
• SMILES: O(CC(N[C@H]1CC[C@H](NC(COC2=CC(F)=C(Cl)C=C2)=O)CC1)=O)C3=CC(F)=C(Cl)C=C3
• Target: Others
• Solubility: DMSO:Slightly soluble

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ISR-IN-1, trans-isrib A17

Compound Identifiers

PubChem CID

90446753