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TPX-0046

SKU: orb1304091

Description

TPX-0046 is a next-generation RET kinase inhibitor developed to target tumors resistant to first-generation agents like selpercatinib and pralsetinib. It is a research tool for investigating resistance mechanisms and evaluating novel therapeutic strategies in both in vitro and in vivo models of RET-driven cancers.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2359650-19-2
MW424.43
Purity99.95% (May vary between batches)
FormulaC21H21FN6O3
SMILESFC=1C=C2CN3C=4C(=CN5C(N4)=C(C=N5)C(=O)NC[C@@H](C)OC2=NC1)O[C@]6([C@@]3(CCC6)[H])[H]
TargetSrc,c-RET
SolubilityDMSO:2 mg/mL (4.71 mM)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RET, TPX 0046, TPX0046, TPX-0046, cRET

Similar Products

  • Compound TPX-0046 [orb1685576]

    99.94%

    2411115-73-4

    424.43

    C21H21FN6O3

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

TPX-0046 (orb1304091)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 200.00
2 mg
$ 280.00
5 mg
$ 420.00
10 mg
$ 620.00
25 mg
$ 1,130.00
50 mg
$ 1,520.00
100 mg
$ 2,020.00
DispatchUsually dispatched within 3-5 working days
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