TPX-0046 (enantiomer)

SKU: orb1304091

Description

TPX-0046 is a next-generation RET kinase inhibitor developed to target tumors resistant to first-generation agents like selpercatinib and pralsetinib. It is a research tool for investigating resistance mechanisms and evaluating novel therapeutic strategies in both in vitro and in vivo models of RET-driven cancers.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2359650-19-2
• MW: 424.43
• Purity: 99.95% (May vary between batches)
• Formula: C₂₁H₂₁FN₆O₃
• SMILES: FC=1C=C2CN3C=4C(=CN5C(N4)=C(C=N5)C(=O)NC[C@@H](C)OC2=NC1)O[C@]6([C@@]3(CCC6)[H])[H]
• Target: c-RET,Src
• Solubility: DMSO:2 mg/mL (4.71 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RET, TPX 0046, TPX0046, TPX-0046, cRET

Compound Identifiers

PubChem CID

153506575