TPPB

SKU: orb1307655

Description

TPPB is a potent, cell-permeable benzolactam derivative that activates protein kinase C (PKC) with a Ki of 11.9 nM. It is widely used as a research tool in cell biology and neuroscience for studying PKC-mediated signaling pathways in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 497259-23-1
• MW: 501.54
• Purity: 99.96% (May vary between batches)
• Formula: C₂₇H₃₀F₃N₃O₃
• SMILES: CC(C)[C@@H]1N(C)c2ccc(NC(=O)\C=C\C=C\c3ccc(cc3)C(F)(F)F)cc2C[C@@H](CO)NC1=O
• Target: PKC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.98 mM);DMSO:125 mg/mL (249.23 mM)

Bioactivity

• Target IC50:
  PKC:11.9 nM (ki)
• In Vivo:
  TPPB is evaluated for the induction of hyperplasia displays a modest response at 300 μg after topical application to the shaved backs of outbred Sencar mice and .
  Read more...
• In Vitro:
  TPPB inhibits the activation of caspase-3 induced by Aβ25-35. TPPB could increase the phosphorylation of Akt, PKC, MARCKS, and MAPK, which are inhibited by Aβ25-35 treatment. TPPB at a concentration of 1 μM could antagonize Aβ25-35 induced cell damage. By the use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB. TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, PKC, TPPB, Protein kinase C

Compound Identifiers

PubChem CID

9935767