TPP-IOA

SKU: orb3136546

Description

TPP-IOA is a cytochrome c peroxidase inhibitor. It prevents apoptosis by blocking cardiolipin oxidation and the release of cytochrome c into the cytosol. TPP-IOA interferes with oxidative phosphorylation in isolated mitochondria. It inhibits cell death of SH-SY5Y cells in glucose medium but is ineffective in galactose medium. Additionally, TPP-IOA induces mitochondrial depolarization and network fragmentation, and it reduces radiation-induced mortality in mice.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1423018-61-4
• MW: 731.78
• Formula: C₄₂H₅₆BrN₂O₂P
• SMILES: [P+](CCCOC(CCCCCCC/C=C\C[C@H](CCCCCC)N1C=CN=C1)=O)(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]
• Target: OXPHOS,Mitochondrial Metabolism,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

OXPHOS,Mitochondrial Metabolism,Apoptosis