TPE-MI

• Catalog Number: orb1983093
• Category: Small Molecules
• Description: TPE-MI (Tetraphenylethene maleimide) is an aggregation-induced luminescent agent that stains living cells, can be used to capture cysteines in exposed unfolded proteins, and detects protein damage after dihydroartemisinin studies of malaria parasites.
• CAS Number: 1245606-71-6
• Purity: 98.00%
• MW: 441.52
• SMILES: O=C1C=CC(=O)N1C2=CC=C(C=C2)C(C=3C=CC=CC3)=C(C=4C=CC=CC4)C5=CC=C(C=C5)C
• Formula: C₃₁H₂₃NO₂
• Biological Activity: Tetraphenylethene maleimide (TPE-MI) serves as a thiol probe to assess unfolded protein levels and proteostasis within cells. It is particularly effective in identifying proteostasis imbalances in both induced pluripotent stem cell models of Huntington's disease and cells transfected with mutant Huntington exon 1, prior to visible aggregate formation. Additionally, TPE-MI is used to detect protein damage in studies involving dihydroartemisinin and the malaria parasites Plasmodium falciparum [1][2]. It should be stored in a manner protected from light.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.