TPB15

SKU: orb1687271

Description

TPB15 is an orally bioavailable small molecule inhibitor of Hedgehog signaling that acts by blocking Smoothened ciliary translocation and reducing its expression. It demonstrates potent anti-proliferative and pro-apoptotic activity in vitro, such as in MDA-MB-468 cells, and shows promising in vivo anti-tumor efficacy with a favorable toxicity profile.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2170347-69-8
• MW: 453.11
• Formula: C₁₈H₉Cl₄N₅O
• SMILES: ClC=1C(C=2N3C(=NN2)C(Cl)=CC=C3)=CC(NC(=O)C4=C(Cl)N=C(Cl)C=C4)=CC1
• Target: Smo,Others,Hedgehog/Smoothened,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156011893