TP0903

SKU: orb1226510

Description

TP-0903 is a potent and selective Axl kinase inhibitor with IC50 of 27 nM.

Key Properties

• CAS Number: 1341200-45-0
• MW: 516.06
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₀ClN₇O₂S
• SMILES: O=S(C1=CC=CC=C1NC2=NC(NC3=CC=C(CN4CCN(C)CC4)C=C3)=NC=C2Cl)(N(C)C)=O
• Target: TAM Receptor
• Solubility: Ethanol: 6 mg/mL warmed (11.62 mM); DMSO: 7 mg/mL warmed (13.56 mM)

Bioactivity

• In Vitro:
  Dubermatinib (TP-0903) displays a potent activity against AXL with an IC50 of 0.027 μM. Dubermatinib (TP-0903) shows extremely potent activity in cell viability assays with an IC50 of 6 nM against the pancreatic cancer cell line PSN-1. Dubermatinib (TP-0903) is evaluated for its ability to block GAS6-mediated activation of AXL in pancreatic cancer cells. PSN-1 cells are serum-starved and then stimulated with GAS6 in the presence of various concentrations of TP-0903.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TP-0903 | TP 0903 | TP0903 | Dubermatinib

Quick Database Links

Gene Symbol

TAM Receptor