TP-10

SKU: orb1308996

Description

TP-10 is a potent and selective phosphodiesterase 10A (PDE10A) inhibitor, exhibiting an IC50 of 0.8 nM. This small molecule is a valuable research tool for studying striatal signaling in neurological and psychiatric disorders, with applications in both in vitro enzymatic assays and in vivo models of conditions like schizophrenia and Huntington's disease.

Research Area

Metabolism Research

Key Properties

• CAS Number: 898563-00-3
• MW: 460.45
• Purity: 99.21% (May vary between batches)
• Formula: C₂₆H₁₉F₃N₄O
• SMILES: FC(F)(F)Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
• Target: PDE
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.17 mM);DMSO:95 mg/mL (206.32 mM)

Bioactivity

• In Vivo:
  TP-10 is active in the mouse behavioral model for positive symptoms. TP-10 demonstrates good in vitro and in vivo activity with extremely high intrinsic clearance (CLint) of t>1000 mL/min/kg in mouse liver microsomes (MLM) in assay.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cAMP, disorder, cGMP, PDE10A, pCREB-LI, inhibit, Inhibitor, U-87 MG, schizophrenia, Phosphodiesterase (PDE), TP 10, TP10, TP-10, reactive oxygen

Compound Identifiers

PubChem CID

11648276