TP-064

SKU: orb1304872

Description

TP-064 is a potent and selective PRMT4/CARM1 inhibitor with an IC50 < 10 nM against histone H3 and 43 nM against MED12 in cells, demonstrating >100-fold selectivity over related enzymes. This tool compound is widely used in vitro and in vivo to investigate the role of PRMT4 in transcriptional regulation, cancer biology, and other epigenetic research areas.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2080306-20-1
• MW: 458.6
• Purity: 99.07% (May vary between batches)
• Formula: C₂₈H₃₄N₄O₂
• SMILES: CNCCN1CCC(CC1)c1cc(CN(C)C(=O)c2cccc(Oc3ccccc3)c2)ccn1
• Target: Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.72 mM);DMSO:125 mg/mL (272.57 mM)

Bioactivity

• Target IC50:
  PRMT4:<10 nM|PRMT6:1300 μM|MED12:43 nM(IC50)|BAF155:340 nM(IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dimethylation, CARM1, BAF155, anticancer, HistoneMethyltransferase, Histone Methyltransferase, MED12, Inhibitor, inhibit, PRMT4, TP064, TP-064, TP 064

Compound Identifiers

PubChem CID

122707126