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TP-0463518

SKU: orb1226101

Description

TP-0463518 is a novel, highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively; demonstrates to promote the production of erythropoietin (EPO) following oral administration in mice and rats, shows potential for treatment of renal anemia.

Images & Validation

Key Properties

CAS Number1558021-37-6
MW431.829
Purity>98% (HPLC)
FormulaC20H18ClN3O6
SMILESClC(C=C1)=CC=C1OC2=NC=C(CN3C(C(C(NCC(O)=O)=O)=C(O)CC3)=O)C=C2
TargetHIF/HIF Prolyl-hydroxylase
SolubilityDMSO: 110 mg/mL (254.73 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TP0463518

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  • TP0463518 [orb1301829]

    99.52% (May vary between batches)

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    431.83

    C20H18ClN3O6

    5 mg, 10 mg, 50 mg, 100 mg, 25 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

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5 mg
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100 mg
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