TP 003

SKU: orb1703970

Description

TP003 is a non-selective benzodiazepine site agonist at GABAA receptors, exhibiting high affinity for several subunit combinations. Its anxiolytic and partial anticonvulsant effects are primarily mediated through α2-containing GABAA receptors, making it a valuable research tool for neuropharmacology studies in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 628690-75-5
• MW: 407.39
• Purity: 99.17% (May vary between batches)
• Formula: C₂₃H₁₆F₃N₃O
• SMILES: FC=1C=2N(C(=CN2)C3=CC(=C(F)C=C3)C4=C(C#N)C=C(F)C=C4)C=CC1C(C)(C)O
• Target: GABA Receptor
• Solubility: DMSO:36.6 mg/mL (89.84 mM);Ethanol:18.4 mg/mL (45.17 mM)

Bioactivity

• In Vivo:
  In rats, TP003, a highly a3-selective agonist in vitro, displays an anxiolytic-like action in the elevated plus maze and in the stress-induced hyperthermia test， and in non-human primate behavioral models of anxiety.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GABA Receptor, GABAReceptor, TP 003, TP003, TP-003

Compound Identifiers

PubChem CID

10001434