Tozasertib

SKU: orb1224379

Description

Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively; also inhibits the imatinib-resistant ABL(T315I) kinase with Kd of 5 nM, displays >100-fold selectivity for the Aurora-A kinase over 55 other kinases with the only exception FLT-3 (Ki=30 nM); blocks cell-cycle progression and induces apoptosis in a diverse range of human tumor types; causes profound inhibition of tumor growth in a variety of in vivo xenograft models.Blood Cancer Discontinued.

Key Properties

• CAS Number: 639089-54-6
• MW: 464.5864
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₈N₈OS
• SMILES: O=C(C1CC1)NC2=CC=C(SC3=NC(NC4=CC(C)=NN4)=CC(N5CCN(C)CC5)=N3)C=C2
• Target: Aurora Kinase
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MK-0457 | VX-680 | MK0457 | VX680 | VX 680 | MK 0457

Quick Database Links

Gene Symbol

Aurora Kinase