Toyocamycin

SKU: orb1307657

Description

Toyocamycin (Vengicide) is an adenosine analog and potent XBP1 inhibitor, blocking IRE1α-mediated XBP1 mRNA splicing with an IC50 of 80 nM. This activity induces apoptosis, making it a valuable tool for studying the unfolded protein response in cancer and other disease models, both in vitro and in vivo.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 606-58-6
• MW: 291.26
• Purity: 99.44% (May vary between batches)
• Formula: C₁₂H₁₃N₅O₄
• SMILES: Nc1ncnc2n(cc(C#N)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
• Target: CDK,Antibiotic,IRE1,Antifungal,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.73 mM);DMSO:122.5 mg/mL (420.59 mM)

Bioactivity

• Target IC50:
  CDK6-CyclinD3:>10 μM|CDK9-CyclinT1:79 nM|XBP1:80 nM|CDK2-CyclinA:0.67 μM|CDK4-CyclinD3:15 μM|CDK7-CyclinH-MAT1:2.8 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclin dependent kinase, drug screening, CDK, CDK9 inhibitor, CDKs, cancer, Apoptosis, Antibiotic, adenosine analog, inhibit, IRE1, mRNA cleavage, molecular docking, epigenetics, extracellular signal-regulated kinases, Fungal, Inhibitor, Inositol requiring enzyme 1, Vengicide, XBP1 activation, XBP1, reactive oxygen species, Toyocamycin, ribosome function, RNA synthesis, RNA Pol II phosphorylation

Compound Identifiers

PubChem CID

11824