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Toyocamycin

SKU: orb1307657

Description

Toyocamycin (Vengicide) is an adenosine analog and potent XBP1 inhibitor, blocking IRE1α-mediated XBP1 mRNA splicing with an IC50 of 80 nM. This activity induces apoptosis, making it a valuable tool for studying the unfolded protein response in cancer and other disease models, both in vitro and in vivo.

Research Area

Cell Biology, Neuroscience, Protein Biochemistry

Images & Validation

Key Properties

CAS Number606-58-6
MW291.26
Purity>98%
FormulaC12H13N5O4
SMILESNc1ncnc2n(cc(C#N)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
TargetUPR (Unfolded protein response)
SolubilitySoluble in DMSO (up to 25 mg/ml)

Bioactivity

Target IC50
CDK6-CyclinD3:>10 μM|CDK9-CyclinT1:79 nM|XBP1:80 nM|CDK2-CyclinA:0.67 μM|CDK4-CyclinD3:15 μM|CDK7-CyclinH-MAT1:2.8 μM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

7-Deaza-7-cyanoadenosine; NSC 63701; NSC 99843; Neuro 000027; Unamycin B; Vengicide

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Toyocamycin (orb1307657)

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5 mg
$ 200.00
25 mg
$ 410.00
DispatchUsually dispatched within 3-5 working days
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