Toremifene citrate

SKU: orb3029194

Description

Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 89778-27-8
• MW: 598.08
• Purity: 99.88%
• Formula: C₃₂H₃₆ClNO₈
• SMILES: C(=C(\c1ccccc1)/CCCl)(\c1ccc(cc1)OCCN(C)C)/c1ccccc1.C(CC(=O)O)(CC(=O)O)(C(=O)O)O
• Target: Estrogen Receptor/ERR,Estrogen/progestogen Receptor,Apoptosis
• Solubility: Ethanol:<1 mg/mL;DMSO:93 mg/mL (155.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.52 mM);H2O:<1 mg/mL

Bioactivity

• Target IC50:
  SERM:1±0.3 μM
• In Vivo:
  In tumor cells, Toremifene (5-10 mM ) was able to upregulate the levels of TRPM-2 and TGF beta1 mRNA. In human breast cancer cells, Toremifene (7.5 mM ) was able to induce apoptosis or programmed cell death. In DMBA-induced rat mammary tumors, Toremifene affected the cell cycle by inhibiting mitotic activity and modifying massive spontaneous apoptosis.
• In Vitro:
  In tumor cells, Toremifene (5-10 mM ) was able to upregulate the levels of TRPM-2 and TGF beta1 mRNA. In human breast cancer cells, Toremifene (7.5 mM ) was able to induce apoptosis or programmed cell death. In DMBA-induced rat mammary tumors, Toremifene affected the cell cycle by inhibiting mitotic activity and modifying massive spontaneous apoptosis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, NK622, NK-622, NK 622, NSC 613680, inhibit, Inhibitor, ERR, ER, FC 1157a, FC-1157a, EstrogenReceptor, Estrogen Receptor/ERR, Estrogen Receptor, progestogen Receptor, progestogenReceptor, Toremifene citrate, Toremifene, Z-Toremifene

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR,Estrogen/progestogen Receptor,Apoptosis