Toremifene citrate

SKU: orb3029194

Description

Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 89778-27-8
• MW: 598.08
• Purity: >99.99% (May vary between batches)
• Formula: C₃₂H₃₆ClNO₈
• SMILES: C(=C(\c1ccccc1)/CCCl)(\c1ccc(cc1)OCCN(C)C)/c1ccccc1.C(CC(=O)O)(CC(=O)O)(C(=O)O)O
• Target: Estrogen Receptor/ERR,Estrogen/progestogen Receptor,Apoptosis
• Solubility: Ethanol:<1 mg/mL;DMSO:93 mg/mL (155.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.52 mM);H2O:<1 mg/mL

Bioactivity

• Target IC50:
  SERM:1±0.3 μM
• In Vivo:
  In tumor cells, Toremifene (5-10 mM ) was able to upregulate the levels of TRPM-2 and TGF beta1 mRNA. In human breast cancer cells, Toremifene (7.5 mM ) was able to induce apoptosis or programmed cell death. In DMBA-induced rat mammary tumors, Toremifene affected the cell cycle by inhibiting mitotic activity and modifying massive spontaneous apoptosis.
• In Vitro:
  In tumor cells, Toremifene (5-10 mM ) was able to upregulate the levels of TRPM-2 and TGF beta1 mRNA. In human breast cancer cells, Toremifene (7.5 mM ) was able to induce apoptosis or programmed cell death. In DMBA-induced rat mammary tumors, Toremifene affected the cell cycle by inhibiting mitotic activity and modifying massive spontaneous apoptosis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, NK622, NK-622, NK 622, NSC 613680, inhibit, Inhibitor, ERR, ER, FC 1157a, FC-1157a, EstrogenReceptor, Estrogen Receptor/ERR, Estrogen Receptor, progestogen Receptor, progestogenReceptor, Toremifene citrate, Toremifene, Z-Toremifene

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR,Estrogen/progestogen Receptor,Apoptosis