Torbafylline

SKU: orb1745205

Description

Torbafylline is a xanthine-based phosphodiesterase (PDE) inhibitor that reduces burn-induced muscle protein breakdown by activating the PDE4/cAMP/EPAC/PI3K/Akt pathway. It also suppresses ubiquitin-proteasome-mediated proteolysis in skeletal muscle during cancer and sepsis, making it a valuable research tool for studying muscle wasting in metabolic and critical illness models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 105102-21-4
• MW: 338.4
• Purity: 99.21% (May vary between batches)
• Formula: C₁₆H₂₆N₄O₄
• SMILES: C(OCC)N1C2=C(N(C)C(=O)N(CCCCC(C)(C)O)C2=O)N=C1
• Target: PI3K|||cAMP|||PDE
• Solubility: DMSO:25 mg/mL (73.88 mM)

Bioactivity

• In Vivo:
  Torbafylline (25 mg/kg per day; oral; three weeks) decreased fatigue to 68%. The blood flow in ligated muscles increased to a much smaller extent than in control muscles, and this smaller increase was attenuated by Torbafylline. A chronic decrease in the blood supply resulted in a significant shortening of the running time. Torbafylline (25 mg/kg p.o.; 2 times a day; 2 weeks) decrease in running time was reversed by chronic treatment of Torbafylline. This improved performance may be explained by a decreased accumulation of lactate in muscles with a limited blood supply due to the effect of Torbafylline to increase the release of lactate from ischaemic muscles.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EPAC, CAMP PDE, PI3K

Compound Identifiers

PubChem CID

65888