toralactone

SKU: orb1680058

Description

Toralactone, a natural compound derived from cassia seeds, exhibits antibacterial properties against methicillin-resistant Staphylococcus aureus (MRSA). This small molecule is a valuable research tool for investigating novel anti-infective agents in both in vitro and in vivo studies.

Research Area

Immunology & Inflammation, Infectious Disease & Virology

Key Properties

• CAS Number: 41743-74-2
• MW: 272.25
• Purity: 98.86% (May vary between batches)
• Formula: C₁₅H₁₂O₅
• SMILES: O=C1OC(=CC=2C=C3C=C(OC)C=C(O)C3=C(O)C12)C
• Target: Nrf2,Antibacterial
• Solubility: DMSO:2.73 mg/mL (10.03 mM)

Bioactivity

• In Vitro:
  Rubrofusarin and toralactone can enhance the cytotoxic profile of P-gp substrates, such as PTX, via inhibiting P-gp efflux activity and enhancing the intracellular entrapment of P-gp substrates. Toralactone sensitize resistant MCF-7adr cell line to paclitaxel via inhibiting P-glycoprotein efflux activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibacterial, Keap1-Nrf2, toralactone

Compound Identifiers

PubChem CID

5321980