Topoisomerase I/II inhibitor 8

SKU: orb2945096

Description

Compound Ru7 is a dual Topoisomerase I/II inhibitor that induces DNA damage and PARP-1 activation, triggering a RIPK1/RIPK3/MLKL-mediated necroptotic cell death pathway. Its nuclear-targeting capability and potent anticancer activity, demonstrated in vitro, offer a promising strategy for overcoming therapy resistance in oncology research.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 355400-87-2
• MW: 497.179
• Formula: C₁₄H₁₁Br₂NO₅S₂
• SMILES: O=C(O)CN1C(=O)C(SC1=S)=CC2=CC(OCC)=C(O)C(Br)=C2Br
• Target: Topoisomerase,PARP,RIP kinase,MLK,Necroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

3802767