Topoisomerase II/EGFR-IN-2

SKU: orb3174489

Description

TopoisomeraseII/EGFR-IN-2 (Compound 3) is an inhibitor targeting Topoisomerase IIα, with an IC50 of 0.122 μM, and EGFR-TKWT, with an IC50 of 16.8 μM. It suppresses the proliferation of HeLa and HepG2 cells, induces cell cycle arrest, and triggers apoptosis. Additionally, it upregulates caspase-3 and Bax while downregulating Bcl-2, making it a potential agent for the study of liver and cervical cancers.

Research Area

Cardiovascular Research, Cell Biology, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• Target: Topoisomerase,EGFR,Bcl-2 Family,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Topoisomerase,EGFR,Bcl-2 Family,Apoptosis,Caspase