Topoisomerase I-IN-18

SKU: orb3173476

Description

TopoisomeraseI-IN-18, a derivative of Thiosemicarbazide, functions as a Topoisomerase I inhibitor, disrupting DNA synthesis and transcription. It suppresses tumor cell proliferation by inducing S phase cell cycle arrest. Additionally, it enhances mitochondria-mediated apoptosis (apoptosis), evidenced by inhibited cell migration and increased intracellular reactive oxygen species (ROS). TopoisomeraseI-IN-18 upregulates p53 protein expression, γH2AX phosphorylation, Bax expression, downregulates Bcl-2 expression, and activates the caspase cascade. This compound is applicable for lung cancer research.

Research Area

Cell Biology, Immunology & Inflammation, Molecular Biology, Protein Biochemistry

Key Properties

• Target: Topoisomerase,MDM-2/p53,ROS,Caspase,DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Topoisomerase,MDM-2/p53,ROS,Caspase,DNA/RNA Synthesis