TOP1/TDP1-IN-1

SKU: orb3211512

Description

TOP1/TDP1-IN-1 is an inhibitor of DNA topoisomerase 1B (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) with a TDP1 IC50 of 17.8 μM. It directly inhibits the catalytic activity of TOP1 without forming a DNA-TOP1 ternary complex. This compound disrupts TDP1-mediated TOP1-induced DNA damage repair, exhibits low acute toxicity, and interferes with DNA repair pathways. It induces apoptosis, inhibits clonogenic capacity, and produces antiproliferative effects in cancer cells. TOP1/TDP1-IN-1 can be utilized in research on non-small cell lung cancer, cervical cancer, and colon cancer.

Key Properties

• CAS Number: 3110679-68-7
• MW: 396.44
• Formula: C₂₂H₂₄N₂O₅
• SMILES: N=1C(OCCN2CCCC2)=C3C=C(OC)C(OC)=CC3=C4C=CC=5OCOC5C14
• Target: DNA/RNA Synthesis,Topoisomerase,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

DNA/RNA Synthesis,Topoisomerase,Apoptosis