Tolimidone

SKU: orb1300367

Description

Tolimidone (NSC 314335) is a small molecule with dual pharmacological activities, functioning as an acid secretion inhibitor and a bronchodilator in animal models. It is utilized in research exploring gastrointestinal and respiratory physiology, particularly in studies involving histamine challenge and gastric acid secretion.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 41964-07-2
• MW: 202.21
• Purity: >99.99% (May vary between batches)
• Formula: C₁₁H₁₀N₂O₂
• SMILES: Cc1cccc(Oc2cnc(=O)[nH]c2)c1
• Target: Src
• Solubility: DMSO:20.2 mg/mL (99.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.89 mM);Ethanol:4 mg/mL (19.78 mM)

Bioactivity

• Target IC50:
  Lyn:63 nM(EC50)
• In Vivo:
  MLR-1023-mediated blood glucose lowering depends on Lyn kinase activity. MLR-1023 is an insulin receptor-potentiating agent that produces a rapid-onset and durable blood glucose-lowering activity in diabetic animals.
• In Vitro:
  In an in vitro broad kinase screen MLR-1023 activated the nonreceptor-linked Src-related tyrosine kinase Lyn. MLR-1023 increased the Vmax of Lyn with an EC50 of 63 nM. This Lyn kinase activation was ATP binding site independent, indicating that MLR-1023 regulated the kinase through an allosteric mechanism.
• Cell Research:
  Adipocyte differentiation is assessed in mouse 3T3-L1 cells after 8 days of incubation with MLR-1023 or rosiglitazone (10 μM).(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP26154, CP-26154, CP 26154, Inhibitor, inhibit, NSC 314335, MLR1023, MLR-1023, MLR 1023, NSC314335, NSC-314335, Lyn kinase, Tolimidone, Src

Compound Identifiers

PubChem CID

39065