TOK-8801

SKU: orb1708342

Description

TOK-8801 (CAS 128-63-6) is a synthetic dihydroimidazole thiazole carboxamide immunomodulator. It functions by depleting T cells, thereby inhibiting antibody production. This mechanism supports its research use in studying autoimmune diseases and transplant rejection in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 105963-46-0
• MW: 315.43
• Purity: 99.99% (May vary between batches)
• Formula: C₁₇H₂₁N₃OS
• SMILES: O=C(NCCC=1C=CC=CC1)C=2SC3=NC(C)(C)CN3C2C
• Target: Microtubule Associated,Others

Bioactivity

• In Vivo:
  TOK-8801 (0.5 mg/kg, p.o.) suppressed the production of anti-SRBC PFC in normal mice, but restored the inhibition of antibody production in restraint stress mice.
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• In Vitro:
  TOK-8801 enhanced the anti-sheep red blood cells (SRBC) plaque forming cells (PFC) response and mitogen-induced proliferative responses in murine splenocytes and thymocytes in vitro at concentrations of 10(-7)-10(-5) M, while LMS augmented these responses at 10(-4) M.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TOK 8801, TOK8801, TOK-8801

Compound Identifiers

PubChem CID

122628