Toddaculin

SKU: orb1297053

Description

Toddaculine is a research compound with potential for osteoporosis and leukemia research. It inhibits osteoclast differentiation via NF-κB and MAPK pathways while promoting osteoblast activity. In vitro studies, such as in U-937 cells, also demonstrate pro-differentiating and apoptotic effects.

Research Area

Cell Biology

Key Properties

• CAS Number: 4335-12-0
• MW: 274.31
• Purity: 99.91% (May vary between batches)
• Formula: C₁₆H₁₈O₄
• SMILES: COc1cc2oc(=O)ccc2c(OC)c1CC=C(C)C
• Target: Apoptosis,Others
• Solubility: DMSO:55 mg/mL (200.5 mM)

Bioactivity

• In Vitro:
  toddaculin displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells, suggesting it may serve as a pharmacological prototype for the development of novel anti-leukemic agents.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Toddaculin, Apoptosis, anti-inflammatory, coumarin, differentiation, leukemic, osteoclast, osteoblast, inhibit, Inhibitor

Compound Identifiers

PubChem CID

5321960