δ-Tocotrienol

SKU: orb1297642

Description

Delta-Tocotrienol is a natural vitamin E variant with demonstrated anti-angiogenic and anticancer properties. Research indicates it activates miR-34a, suppressing proliferation, inducing apoptosis, and inhibiting invasion in non-small cell lung cancer cells in vitro, highlighting its potential as a chemopreventive agent.

Research Area

Cardiovascular Research, Cell Biology, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 25612-59-3
• MW: 396.61
• Purity: 99.86%
• Formula: C₂₇H₄₀O₂
• SMILES: CC(C)=CCC\C(C)=C\CC\C(C)=C\CC[C@]1(C)CCc2cc(O)cc(C)c2O1
• Target: Others,Akt,PI3K,p53,PDK,Bcl-2 Family,ERK,VEGFR,NF-κB,Apoptosis,Caspase,DNA/RNA Synthesis
• Solubility: DMSO:100 mg/mL (252.14 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (8.32 mM)

Bioactivity

• In Vitro:
  δ-Tocotrienol induced apoptosis and cell cycle arrest at G0/G1 and M phases in nasopharyngeal carcinoma cells. After CNE1 cells were treated with δ-Tocotrienol, 169 genes were up-regulated and 167 down-regulated. ERK1/2 was shown to play a vital role in cell cycle arrest by gene chips. δ-Tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. CNE1 apoptosis was related to dysregulated expression of Bax-2 and Bcl-2. Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of δ-Tocotrienol.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3K, PDK, δ Tocotrienol, δTocotrienol, Δ-Tocotrienol, δ-Tocotrienol, VEGFR, Delta-Tocotrienol, Bcl-2, Akt, ERK, Inhibitor, p53, inhibit

Compound Identifiers

PubChem CID

5282350