TNO155

SKU: orb1309000

Description

TNO155 is a potent and selective small molecule inhibitor of the SHP2 (PTPN11) phosphatase, exhibiting an IC50 of 11 nM. It is widely used in cancer research to investigate oncogenic signaling pathways, demonstrating antitumor activity in both cellular assays and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1801765-04-7
• MW: 421.95
• Purity: 99.24%
• Formula: C₁₈H₂₄ClN₇OS
• SMILES: C[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3ccnc(N)c3Cl)c(N)n2)[C@@H]1N
• Target: Phosphatase
• Solubility: DMSO:50 mg/mL (118.5 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (5.92 mM)

Bioactivity

• Target IC50:
  SHP2:0.011 µM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Batoprotafib, BCS, Aberrant, allosteric, activation, CRC, Inhibitor, HNSCC, malignancy, EGFR-mutant, inhibit, NSCLC, TNO155, TNO-155, TNO 155, RTK-dependent, Phosphatase, SHP2, SHP-2

Compound Identifiers

PubChem CID

118238370