TNKS-2-IN-3

SKU: orb3135962

Description

TNKS-2-IN-3 (Compound 5) is a selective and competitive inhibitor of Tankyrase 2 (TNKS2), with an IC50 value of 0.3 nM. It exhibits over 20-fold selectivity for TNKS2 compared to TNKS1 and more than 100-fold selectivity over PARP1/2. By inhibiting TNKS2-mediated ADP ribosylation, TNKS-2-IN-3 stabilizes axin and suppresses the Wnt/β-catenin pathway, demonstrating antiproliferative activity in colorectal cancer cells. TNKS-2-IN-3 holds potential for research in solid tumors with aberrant Wnt pathway activation, such as colorectal cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2580941-64-4
• MW: 494.63
• Formula: C₂₄H₂₆N₆O₂S₂
• SMILES: O=C1N=C(SCCN2CCN(CCSC3=NC(=O)C=4C=CC=CC4N3)CC2)NC=5C=CC=CC15
• Target: PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PARP