TNKS-2-IN-1

SKU: orb1819001

Description

TNKS-2-IN-1 is a dual inhibitor of tankyrase 1 and 2 (IC50s: 259 nM and 1100 nM, respectively) and also suppresses NLRP3 inflammasome-mediated IL-1β release (IC50: 5 μM). This compound exhibits antimicrobial activity against E. coli and S. aureus, making it a useful research tool for studying Wnt signaling, inflammation, and host-pathogen interactions in cellular models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 4765-59-7
• MW: 267.24
• Purity: 98.40% (May vary between batches)
• Formula: C₁₄H₉N₃O₃
• SMILES: [O-][N+](=O)c1ccc(cc1)-c1nc(=O)c2ccccc2[nH]1
• Target: Antibiotic,Wnt/beta-catenin,PARP
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  TNKS2:1100 nM|TNKS1:259 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

βcatenin, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, TNKS1, TNKS2, TNKS2IN1, TNKS-2-IN-1, betacatenin, beta-catenin, Antibiotic, bcatenin, PARP

Compound Identifiers

PubChem CID

135402338