TNIK-IN-5

SKU: orb1297864

Description

TNIK-IN-5 is a potent and selective TNIK inhibitor with an IC50 of 0.05 µM, effectively suppressing Wnt signaling in cellular assays. It demonstrates significant anti-proliferative activity against colorectal cancer cells in vitro, making it a valuable chemical probe for studying Wnt-driven oncogenesis and CRC-related research.

Research Area

Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2754265-66-0
• MW: 371.39
• Purity: 99.75% (May vary between batches)
• Formula: C₂₂H₁₇N₃O₃
• SMILES: C(N1C=2C(=CC(=CC2)C=3C=C4C(=NC3)NC=C4)OC1=O)C5=CC(OC)=CC=C5
• Target: Wnt/beta-catenin
• Solubility: 10% DMSO+90% Corn Oil:1 mg/mL (2.69 mM);DMSO:10 mg/mL (26.93 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

βcatenin, Wnt, Wnt pathway, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, TNIK-IN-5, TNIKIN5, TNIK IN 5, TNIK, inhibit, Migration, Inhibitor, HCT116?cells, Cell proliferation, beta-catenin, betacatenin, Colorectal cancer, bcatenin

Compound Identifiers

PubChem CID

163322020