TNIK-IN-2

SKU: orb1298024

Description

TNIK-IN-2 is a small molecule inhibitor of TNIK (IC50 = 1.33 μM), a key kinase in the Wnt/β-catenin signaling cascade. This compound is a useful research tool for investigating Wnt pathway biology in both cellular and animal models of diseases such as cancer.

Research Area

Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2754265-76-2
• MW: 373.4
• Purity: 99.54% (May vary between batches)
• Formula: C₂₂H₁₉N₃O₃
• SMILES: O(C)C=1C=C(C=2C=C3C(=NC2)NC=C3)C=CC1C(NC4=CC(OC)=CC=C4)=O
• Target: Serine Protease,Others,Wnt/beta-catenin
• Solubility: DMSO:50 mg/mL (133.9 mM)

Bioactivity

• Target IC50:
  TNIK:1.33 μM|TNIK:31.26 μM(HCT116 cells)
• In Vitro:
  In HCT116 cells, the IC50 value was 31.26 μM for TNIK.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta-catenin, betacatenin, bcatenin, Inhibitor, inhibit, Wnt, Wnt/β-catenin, Wnt/b-catenin, Wnt/betacatenin, TNIKIN2, TNIK-IN-2, TNIK, TNIK IN 2, βcatenin

Compound Identifiers

PubChem CID

162641719