TNI-97

SKU: orb3136142

Description

TNI-97 is a selective, orally active HDAC6 inhibitor with an IC50 value of 0.2 nM. It significantly suppresses the growth and colony-forming abilities of the triple-negative breast cancer (TNBC) cell line MDA-MB-453. In these cells, TNI-97 induces widespread cell death, including apoptosis, necroptosis, and pyroptosis. Additionally, TNI-97 demonstrates antitumor activity in mouse models bearing MDA-MB-453 xenograft tumors or syngeneic mouse-derived TNBC cell allograft tumors. TNI-97 is useful for researching triple-negative breast cancer.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Musculoskeletal & Connective Tissue Research

Key Properties

• CAS Number: 2790425-52-2
• MW: 416.36
• Formula: C₁₉H₁₅F₃N₆O₂
• SMILES: O=C(NO)C1=CC=C(C=C1)CN2N=C(C=C2C(F)(F)F)C3=CC=C4C(N=NN4C)=C3
• Target: Apoptosis,Pyroptosis,HDAC,Necroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Pyroptosis,HDAC,Necroptosis